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KMID : 1146920230530060781
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Journal of Pharmaceutical Investigation
2023 Volume.53 No. 6 p.781 ~ p.801
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Recent advancements of nitric oxide-releasing hydrogels for wound dressing applications
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Nurhasni Hasan
Cao Jiafu
Apon Zaenal Mustopa
Achmad Himawan
Rifqiyah Nur Umami
Muneeb Ullah
Nasrul Wathoni
Yoo Jin-Wook
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Abstract
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Background : Hydrogels are three-dimensional (3D) polymer networks that can absorb significant volumes of water inside their interstices and continue connecting these interstices while maintaining an inflated network structure; this capability is due to their unusual 3D crosslinked polymer meshwork structure. Hydrogels are promising wound dressings, particularly for chronic wounds, owing to their wound-healing properties, such as flexibility, adhesion, moisture control, biocompatibility, and biodegradability. Nitric oxide (NO) is a small molecule that has been thoroughly investigated for its wound-healing activity. The diverse roles of NO in wound healing require its stable delivery to the wound site. Thus, hydrogels have been evaluated as promising scaffolds for storing and releasing NO in a controlled manner to promote and accelerate wound healing.
Area covered : This review sought to introduce the types of polymers used to prepare hydrogel-based wound dressings and the types of NO donors used as wound healing promoters. The preparation method of the hydrogels and their physical and chemical properties were presented herein, and recent studies on NO-releasing hydrogels for wound therapy were summarized and discussed. Selected hydrogels with unique characteristics and significant findings for wound healing were also emphasized.
Expert opinion : Owing to the importance of chronic wounds in healthcare, the development of functional materials that support proper and rapid wound healing is required. NO-releasing hydrogels can be employed for wound dressing applications owing to their controlled NO releasability and antibacterial and wound healing activities.
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KEYWORD
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Nitric oxide, Polymer, Hydrogel, Wound healing, Wound dressing
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